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Aug 24, 2017
Prof. Brian Kobilka’s group revealed the mechanism of intracellular allosteric ...

On August 17th, 2017, Prof. Brian Kobilka’s research group in school of Medicine, Tsinghua University published a paper in Nature, entitled “Mechanism of intracellular allosteric β2AR antagonist re...
Aug 20, 2017
Xuebin LIAO research group publishes “In situ generation of N-unsubstituted imines from alkyl azides & applications for imine transfer” in Science Advances

Although azides have been widely used in nitrene transfer reactions, in situ generation of N-H imines from azides for downstream transformations has rarely been explored. We report copper-mediated for...
Jun 30, 2017
Liansuo Zu research group publishes “ Catalytic Enantioselective Aza-pinacol Rearrangement” in Angew. Chem. Int. Ed.

The first catalytic enantioselective asymmetric aza-pinacol rearrangement is reported. The reactions are catalyzed by a chiral phosphoric acid and proceed via a highly organized transition state invol...
Jun 15, 2017
Germ cell breakthrough paves way to infertility treatment...

Source: XinhuaBEIJING, June 13 (Xinhua) -- Scientists at Tsinghua University have led the world in inducing in-vitro differentiation of human embryonic stem cells into follicle-like cells. The breakth...
May 18, 2017
Yefeng Tang research group publishes “Total Synthesis of Homodimericin A” in Angew. Chem. Int. Ed.

We report the concise total synthesis of homodimericin A, a recently identified fungal metabolite bearing an unprecedented molecular architecture. The success of the approach hinges on a series of ra...
Apr 29, 2017
Ligong CHEN research group discovers the mechanism process of renal toxicity induced by adefovir and tenofovir

Despite the therapeutic success of tenofovir (TFV) for treatment of HIV-1 infection, numerous cases of nephrotoxicity have been reported. Mitochondrial toxicity has been purported as the major target ...
Apr 29, 2017
Ligong CHEN publishes “A "functional signaling indispensable is for c-Myc driven hepatocarcinogenesis" in Hepatology

Amplification and/or activation of the c-Myc protooncogene is one of the leading genetic events leading to hepatocarcinogenesis. The oncogenic potential of c-Myc has been proven experimentally by the ...
Apr 29, 2017
Yefeng TANG publishes “Denitrogenative Suzuki and carbonylative Suzuki coupling reactions of benzotriazoles with boronic acids” in Chemical Science

Unprecedented palladium-catalyzed denitrogenative Suzuki and carbonylative Suzuki coupling reactions of benzotriazoles with boronic acids have been realized, leading to the possibility of structurally...
Apr 29, 2017
Gang LIU research group releases first report on NOD2 targeted tumor treatment

A noncleavable paclitaxel (PTX) and N-acetylmuramyl-l-alanyl-d-isoglutamine (MDP) derivative conjugate, 22 (DY-16-43), and its analogues were prepared and characterized as antagonists of NOD2 signalin...
Apr 06, 2017
Beijing-based Global Health Drug Discovery Institute to Develop Accessible Innovative Drugs for Developing Nations

BEIJING – A meeting between the Beijing Municipal Government, Bill & Melinda Gates Foundation (Gates Foundation), and Tsinghua University officially marked the inauguration of the Global Health Drug ...

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Prof. Brian Kobilka’s group revealed the mechanism of intracellular allosteric ...

On August 17th, 2017, Prof. Brian Kobilka’s research group in school of Medicine, Tsinghua University published a paper in Nature, entitled “Mechanism of intracellular allosteric β2AR antagonist re...

Xuebin LIAO research group publishes “In situ generation of N-unsubstituted imines from alkyl azides & applications for imine transfer” in Science Advances

Although azides have been widely used in nitrene transfer reactions, in situ generation of N-H imines from azides for downstream transformations has rarely been explored. We report copper-mediated for...

Liansuo Zu research group publishes “ Catalytic Enantioselective Aza-pinacol Rearrangement” in Angew. Chem. Int. Ed.

The first catalytic enantioselective asymmetric aza-pinacol rearrangement is reported. The reactions are catalyzed by a chiral phosphoric acid and proceed via a highly organized transition state invol...

Germ cell breakthrough paves way to infertility treatment...

Source: XinhuaBEIJING, June 13 (Xinhua) -- Scientists at Tsinghua University have led the world in inducing in-vitro differentiation of human embryonic stem cells into follicle-like cells. The breakth...

Yefeng Tang research group publishes “Total Synthesis of Homodimericin A” in Angew. Chem. Int. Ed.

We report the concise total synthesis of homodimericin A, a recently identified fungal metabolite bearing an unprecedented molecular architecture. The success of the approach hinges on a series of ra...

Ligong CHEN research group discovers the mechanism process of renal toxicity induced by adefovir and tenofovir

Despite the therapeutic success of tenofovir (TFV) for treatment of HIV-1 infection, numerous cases of nephrotoxicity have been reported. Mitochondrial toxicity has been purported as the major target ...

Ligong CHEN publishes “A "functional signaling indispensable is for c-Myc driven hepatocarcinogenesis" in Hepatology

Amplification and/or activation of the c-Myc protooncogene is one of the leading genetic events leading to hepatocarcinogenesis. The oncogenic potential of c-Myc has been proven experimentally by the ...

Yefeng TANG publishes “Denitrogenative Suzuki and carbonylative Suzuki coupling reactions of benzotriazoles with boronic acids” in Chemical Science

Unprecedented palladium-catalyzed denitrogenative Suzuki and carbonylative Suzuki coupling reactions of benzotriazoles with boronic acids have been realized, leading to the possibility of structurally...

Gang LIU research group releases first report on NOD2 targeted tumor treatment

A noncleavable paclitaxel (PTX) and N-acetylmuramyl-l-alanyl-d-isoglutamine (MDP) derivative conjugate, 22 (DY-16-43), and its analogues were prepared and characterized as antagonists of NOD2 signalin...

Beijing-based Global Health Drug Discovery Institute to Develop Accessible Innovative Drugs for Developing Nations

BEIJING – A meeting between the Beijing Municipal Government, Bill & Melinda Gates Foundation (Gates Foundation), and Tsinghua University officially marked the inauguration of the Global Health Drug ...

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